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KMID : 0363219700080020063
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Korean Journal of Dermatology
1970 Volume.8 No. 2 p.63 ~ p.68
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Malignant Acanthosis Nigricans Associated with Severe Oral Florid Papilloma
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朴旭和/Bark, Wook Hwa
金永來/尹奉燦/禹泰河/Kim, Yung Lae/Yoon, Bong Chan/Woo, Tae Ha
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Abstract
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One case of malignant acanthosis nigricans associated with internal malignany and oral florid papilloma has been presented and reviewed the subject of malignant acanthosis nigricans.
The patient who was 34 year old man had been affected generalized dark brownish hyperpigmentation with papillnmatoses especially on forehead, neck, axillae, umbilical area, anogenital area, webs of fingers, palms and soles. And characteristically it wasassociated with severe florid papilloma on mucous membrane such as buccal mucoua, lip and glans penis.
Histopathologically, internal malignancy was confirmed metastatic adenocarcinoma of stomach after autopsy, although previous biopsy finding was squamous cell carcinoma when explorative laparatomy was done.
The response to Bleomycin, new antibiotic anticancer drug, followed by intravenous injection is good and satisfying. But the patient died due to sudden pulmonary hemorrhage which are serious side effect of Bleomycin.
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